Over the past ten years, scientists have proposed a diversity of methods to identify peptide ligands by designing multiple peptide libraries. Random library contain a large number of peptides ranging from 1 million to 1 billion different sequences that can be screened using monoclonal and polyclonal antibodies, receptors, enzymes or other target molecules. This technique is developed based on the chemical diversity of amino acids and the large number of sequences in the library. Thus, random peptide libraries have been widely applied to find ligands that can be used as leads for drug development and other purposes.
Applications
- Peptide sequence optimization
- Target identification
- Peptide drug design
Figure 1. Random peptide library of ICK motif peptides. (Tai, K. 2017)
Library Design
- BOC Sciences random libraries are constructed with as many mutations as possible in the selected amino acids, in which the alternative peptides have potential in enhancing peptide activity
- We produce this unique library to simultaneously and randomly spontaneous replace amino acids residues with 20 natural amino acids using the ‘shotgun’ method
- Our computational chemistry team can also support a random library with specific physical and chemical properties as well as certain sizes and properties
Custom Library Synthesis and Delivery
- At BOC Sciences, peptide arrays are provided in a variety of sizes and formats according to the demand of different projects
- Peptide lengths can be ranging from 5 to 30 amino acids, which can meet most requirement of applications
- Our expert teams can provide peptide library containing up to 50 amino acid if there is special demand
- Standard delivery times of around 3-4 weeks depending on different library size and peptide length
- Delivered as freeze-dried in 96-well plates for subsequent experiments
- MS and HPLC analysis results are provided for each peptide product
- All peptides in the library can be de-TFA salt treatment, also can be converted to acetate according to the customer's requirements
BOC Sciences provides professional, rapid and high-quality services of Random Library design at competitive prices for global customers. Personalized and customized services of Random Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!
Reference
- Tai, K. Random Peptide Library for Ligand and Drug Discovery. 2017.
