Antimalarial Screening Compound Library

Malaria is a tropical disease caused by infection of the protozoan parasites of the genus Plasmodium, which are spread to people through the bites of infected female Anopheles mosquitoes (called ‘malaria vectors’). Approximately 210 million people are infected with malaria each year in which nearly 450,000 people die from malaria caused by Plasmodium parasites. Five parasite species are capable of causing malaria in humans, with Plasmodium falciparum and Plasmodium falciparum posing the greatest threat to life safety. P. falciparum can cause a more severe form of the disease, and those infected with this form of malaria tend to have a higher risk of death. Scientists around the world have high research interest in finding antimalarial compounds.

BOC Sciences’ Antimalarial Screening Compound Library is designed and established for various antimalarial studies and HTS in drug discovery.

Applications

• Drug-like compounds as starting points for oral drug discovery and development
• Probe-like compounds for use as biological tools in malaria research

Figure 1. Life Cycle of Plasmodium Spp. Parasites. (Drawz, P. E.; Sedor, J. R. 2011)

Library Design

1. Our library is built based on known structure/activity data of antimalarial compounds and contains a diversity of drug-like screening compounds with high structural similarity to these compounds
2. At BOC Sciences, a reference set of molecules with reported antimalarial activity are collected from a wide range of commercially available databases
3. 2D molecular fingerprints search has been employed for compound selection
4. About 7,900 molecules can be generated that are predicted to be active against the following Plasmodium species:

Antimalarial Screening Compound Library Characteristics

• No PAINS or toxic substances/unwanted functions: filtered by strict ‘Ro5-like’ physicochemical and most stringent in-house structural filters
• Confirmed bioactivity and safety via preclinical studies and clinical trials
• All of the compounds have confirmed activity against the blood-stage of P. falciparum
• Structural diversity, significant efficacy, and cellular penetration
• Structural document, IC₅₀, and other chemical and biological data are provided
• Tanimoto index ≥ 0.85
• All compounds are continually updated
• Compound cherry-picking service is provided

What We Deliver

• Delivered within 2 weeks in any customer-preferred format
• Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
• All compounds have a minimum purity of 90% assessed by ¹H NMR and HPLC
• Analytical data is provided

BOC Sciences provides professional, rapid and high-quality services of Antimalarial Screening Compound Library design at competitive prices for global customers. Personalized and customized services of Antimalarial Screening Compound Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!