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Neuroprotection Compound Library

The molecular mechanisms of programmed cell death associated with neurodegenerative diseases have been one of the hot topics of research for many years. Neurodegenerative diseases are characterized by progressive neuronal dysfunction and death of neurons, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis (MS). Neuroprotection can protect neurons from different pathological factors in neurodegenerative diseases. Current studies have shown that in the treatment of neurodegenerative diseases, neuroprotective agents cannot reverse existing damage, but they can protect against further neurological damage and slow down the degenerative effects of the central nervous system.

BOC Sciences can provide a high-quality neuroprotection compound library which can be used as a useful tool in neuroprotective drug discovery.

Representation of the mechanism of neuroprotection in oxidative stress. Figure 1. Representation of the mechanism of neuroprotection in oxidative stress. (Egea, J.; et al. 2015)

Library Design

  1. Our unique neuroprotection compound library contains 700 compounds, which is designed for high throughput screening (HTS) and high content screening (HCS) campaigns
  2. Targets including: calcium channel, sodium channel, adenosine A1 receptor, PI3K, etc
  3. The composition of this neuroprotection compound library:
  • Calcium Channel
  • Sodium Channel
  • iGluR
  • Apoptosis
  • Potassium Channel
  • Wnt
  • Endogenous Metabolite
  • Autophagy
  • GABA Receptor
  • β-catenin
  • NO Synthase
  • mGluR
  • Reactive Oxygen Species
  • NF-κB
  • Bacterial
  • Adenosine Receptor
  • COX
  • Akt
  • ERK
  • Parasite
  • Cytochrome P450
  • Phosphodiesterase (PDE)
  • Monoamine Oxidase
  • Sigma Receptor
  • 5-HT Receptor
  • TRP Channel
  • AChE
  • Adrenergic Receptor
  • Amyloid-β
  • Dopamine Receptor
  • GSK-3
  • HIV
  • PARP
  • Antibiotic
  • Influenza Virus
  • PI3K
  • Ferroptosis
  • TGF-beta/Smad
  • TNF Receptor
  • Angiotensin Receptor
  • Drug Metabolite
  • Interleukin Related
  • mAChR
  • P2X Receptor
  • Porcupine
  • PPAR
  • Virus Protease
  • Casein Kinase
  • Caspase
  • DNA/RNA Synthesis
  • HCV
  • HSV
  • MDM-2/p53
  • MEK
  • Mitochondrial Metabolism
  • MMP
  • P-glycoprotein
  • p38 MAPK
  • Sirtuin
  • STAT
  • Trk Receptor
  • AMPK
  • T Angiotensin-converting Enzyme (ACE)
  • Beta-secretase
  • Cannabinoid Receptor
  • Carbonic Anhydrase
  • CDK
  • Chloride Channel
  • Estrogen Receptor/ERR
  • Fungal
  • Glucosidase
  • HDAC
  • Histamine Receptor
  • Histone Methyltransferase
  • HSP
  • JAK
  • JNK
  • LPL Receptor
  • MAP4K
  • Mitophagy
  • nAChR
  • NOD-like Receptor (NLR)
  • Notch
  • PKC
  • Prostaglandin Receptor
  • ROCK
  • Acetyl-CoA Carboxylase
  • Aldose Reductase
  • Androgen Receptor
  • Aryl Hydrocarbon Receptor
  • Bcl-2 Family
  • Carboxypeptidase
  • Cathepsi

Neuroprotection Compound Library Characteristics

  • No PAINS or toxic substances/unwanted functions: filtered by strict ‘Ro5-like’ physicochemical and most stringent in-house structural filters
  • Confirmed bioactivity and safety by preclinical studies and clinical trials
  • Structural diversity, significant efficacy, and cellular penetration
  • Structural document, IC50, and other chemical and biological data are provided
  • Tanimoto index ≥ 0.8
  • All compounds are continually updated
  • Compound cherry-picking service is provided

What We Deliver

  • Delivered within 2 weeks in any customer-preferred format
  • Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
  • All compounds have a minimum purity of 90% assessed by 1H NMR and HPLC
  • Analytical data is provided

BOC Sciences provides professional, rapid and high-quality services of Neuroprotection Compound Library design at competitive prices for global customers. Personalized and customized services of Neuroprotection Compound Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!

Reference

  1. Egea, J.; et al. Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a 'drug-prodrug' mechanism of action. British Journal of Pharmacology. 2015. 172(7): 1807-1821.
Our mission is to provide clients with a professional chemical library design platform. Empowered by high-quality services and effective research solutions, we are committed to helping customers achieve effective and successful research goals.

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Services Based on the Chemical Library Design Platform

Services Based on the Chemical Library Design Platform

BOC Sciences has rich experience in working with global customers in custom library synthesis of compounds and generating small to medium-sized libraries of target compounds. Our knowledge in generating a large number of target molecules in a remarkably shorter time enables quick biological screenings for affinities. With the target properties in mind, we deliver target molecules, by applying our extensive knowledge in drug discovery.

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