DNA-compatible Reactions

One of the biggest advantage of DEL technology is that it can screen out a large number of compounds in a low-cost and high-efficiency way. The structural diversity of library molecules plays a key role in the DEL construction. The DNA-encoded library is developed based on a Split&Mixing method to synthesize a large number of building blocks in an aqueous system using a combinatorial chemistry method. Therefore, the diversity of building block compounds and DNA compatibility are the basis of the molecular diversity of drug-like libraries. The main challenge faced by DEL technology is to construct a compound library with diverse structures and high quality, ensuring reaction conditions compatible with DNA. The chemical reactions applicable to DEL technology are limited to reactions compatible with DNA. DNA is a water-soluble molecule, so traditional organic reactions should be converted to corresponding conditions. In recent years, BOC Sciences has made progress in the expansion of DEL synthesis technology and we have built hundreds of reaction kits for the synthesis of DEL.

Prospects of DEL Synthetic Chemistry

• Construction of a small-scale, diversity-oriented new-generation DEL
• The new generation of DNA-encoding technologies such as OBOC and RASS (reverse adsorption to solid support) have expanded the application scenarios of DNA-encoding libraries
• There is a huge potential for development in the generation and mode of new molecular types

Figure 1. DNA-encoded reaction rehearsal. (Malone, M. L.; Paegel, B. M. 2016)

Our Services

To make it easier and better for researchers, BOC Sciences provides DNA-compatible bonding formation, DNA-compatible functional group transformation and DNA-compatible core structure construction services in a competitive fashion. Our rapid and high quality services are as follow:

DNA-compatible bonding formation

Bond formation reactions has always been one of the core contents of medicinal chemistry. However, many of reactions are difficult to achieve during DEL construction due to the limitation of DNA stability and solubility. In addition, considering the advantages of mild reaction conditions and a wide range of substrates, visible light redox catalysis has become an indispensable method in organic synthetic chemistry.

• With years of knowledge of synthetic chemistry, we have successfully developed hundreds of DNA-compatible bond-forming chemical reactions, such as the construction of C-C bonds, C-N bonds, C-O bonds, and C-S bonds.
• With a deep understanding of the mechanism of visible light redox catalysis. Our R&D team has achieved DNA-compatible C-H activation, alkene addition, cross-coupling and other bonding methods.

DNA-compatible functional group transformation

The conversion of DNA-compatible functional groups can greatly enrich the types of substrates substituted by using multi-functional groups. Aiming to expand the diversity of substrate structures and reduce the cost of building blocks, BOC Sciences has established a set of reactions for the mutual transformation of various functional groups. We are able to expand the conversion reaction of functional groups through a limited number of commercially available building block compounds. Moreover, we can obtain many commercially available compounds and expand a wider range of chemical conversion types.

DNA-compatible core structure construction

Our scientists have made great progress in the construction of DNA-compatible core structures, such as C3-alkylated indole, 2-aminobenzimidazole, indazolone, polysubstituted pyrimidine and other medicinal chemical characteristic structures.

BOC Sciences provides professional, rapid and high-quality services of DNA-compatible reactions services at competitive prices for global customers. Personalized and customized services of DNA-compatible reactions can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!