The application of the Ugi reactions in the construction of new peptide scaffolds is an important goal of organic chemistry. Ugi four-component reaction (U-4CR) are widely considered to be very effective for the synthesis of pseudopeptides. The biological activity of any given molecule essentially depends on the 3D shape of its protein-protein interaction (PPI) library, and the molecular shape diversity of a small molecule library is the overall functional diversity. The molecular shape diversity of a small molecule library is the most fundamental indicator of overall functional diversity.
BOC Sciences is committed to designing a high-quality circlic-ugi PPI library.
Figure 1. Clinical status of peptide with protein-protein interaction properties. (Cabri, W.; et al. 2021)
Library Design
- Scaffold diversity: Presence of a range of different molecular scaffolds
- Functional group diversity: Variation in the functional groups
- Appendage diversity (substituent or building-block diversity): Variation in structural parts around the common scaffold
- Stereochemical diversity: Variation in the orientation of potential macromolecular interaction elements
- Conformational diversity: Variation of possible conformation of the molecule
- Chain diversity: Presence of different chains (especially if the scaffold is not uniquely identified)
Cyclic-Ugi PPI Library Characteristics
- No PAINS or toxic substances/unwanted functions: filtered by strict ‘Ro5-like’ physicochemical and most stringent in-house structural filters
- Bioactivity and safety confirmed by preclinical studies and clinical trials
- Structural diversity, medicinal activity, and cellular penetration
- Structural document, IC50, and other chemical and biological data are provided
- All compounds are continually updated
- All of these compounds with Tanimoto index ≥ 0.85
- Compound cherry-picking service is provided
What We Deliver
- Delivered within 2 weeks in any customer-preferred format
- Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
- All compounds have a minimum purity of 90% assessed by 1H NMR and HPLC
- Analytical data is provided
BOC Sciences provides professional, rapid and high-quality services of Cyclic-Ugi PPI Library design at competitive prices for global customers. Personalized and customized services of Cyclic-Ugi PPI Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!
Reference
- Cabri, W.; et al. Therapeutic Peptides Targeting PPI in Clinical Development: Overview, Mechanism of Action and Perspectives. Frontiers in Molecular Biosciences. 2021. 8: 697586.
