Aurora A Kinase Targeted Library

The Aurora kinase family consists of three serine/threonine kinases: Aurora-A, Aurora-B and Aurora-C. Among them, Aurora-A and Aurora-B play an important role in mitosis, while Aurora-C performs a unique role in meiosis. Clinical data have shown that Aurora kinases are overexpressed or genetically amplified in a wide range of human malignancies, indicating their role as potent oncogenes in tumorigenesis. Thus, Aurora kinases are promising targets for anticancer therapy. Given that various studies have revealed novel functions of Aurora kinases in cancer development and the mechanisms underlying the anticancer effects of AKI, the oncogenic role and signaling pathways of Aurora-A kinases in promoting tumorigenesis are being investigated by scientists. Moreover, the use of selective Aurora A inhibitors may avoid the use of Aurora B-mediated neutropenia in clinical settings.

BOC Sciences has developed a library of potential selective inhibitors of Aurora A kinase from our compounds collection.

Figure 1. Current model of kinase activation. (James, A, H.; et al. 2017)

Library Design

At BOC Sciences, our Aurora A kinase targeted library is designed based on the specific conformation of the ATP binding sites of Aurora A recorded in various database, and we can produce more specific ligands by using a variety of conformational changes in the active site of the protein induced by the binding of pyrimidine-based ligands.

1. Firstly, we employ a docking approach to identify the key amino acids involved in inhibitor binding
2. Then, a query model of protein binding sites is well prepared using multiple screening tools based on protein-ligand interactions
3. The docking procedure is applied for the pre-filtered set of compounds from the BOC Sciences HTS compound collection

The following residues are found to be important for the hydrogen bonding network:

Ala213, Pro214, Glu211, Arg137, Gly142 and Lys143

In addition, hydrophobic regions of protein active sites are also included in the docking constraints

Aurora A Kinase Targeted Library Characteristics

• Favorable physicochemical parameters and solubility requirements
• No PAINS or toxic substances/unwanted functions: filtered by strict ‘Ro5-like’ physicochemical and most stringent in-house structural filters
• Bioactivity and safety confirmed by preclinical studies and clinical trials
• Structural diversity, medicinal activity, and cellular penetration
• Structural document, IC₅₀, and other chemical and biological data are provided
• All compounds are continually updated
• Compound cherry-picking service is provided

What We Deliver

• Delivered within 2 weeks in any customer-preferred format
• Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
• All compounds have a minimum purity of 90% assessed by ¹H NMR and HPLC
• Analytical data is provided

BOC Sciences provides professional, rapid and high-quality services of Aurora A Kinase Targeted Library design at competitive prices for global customers. Personalized and customized services of Aurora A Kinase Targeted Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!