2D Similarity-based Anti-inflammatory Focused Library

Inflammation is the immune system's natural response to injury and disease. Inflammatory chemicals in the bloodstream protect a person's body from foreign invaders such as bacteria and viruses. When the body is injured, a localized inflammatory response plays a vital role in the healing process. There are two types of inflammation: acute and chronic. Studies have shown that chronic inflammation plays a role in several health conditions, including arthritis, heart disease, type 2 diabetes, cancer and Alzheimer's disease. Clinically, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids and topical medications, including analgesics and steroids, are commonly used to treat acute inflammation. Challenges and trends in the development of anti-inflammatory drugs include the poor clinical predictability of experimental models of inflammatory diseases.

BOC Sciences can design and produce its 2D similarity-based anti-inflammatory focused library for novel anti-inflammatory drugs screening and discovery research.

Figure 1. Nonsteroidal anti-inflammatory drug-induced anticancer effects. (Xiangjie, F.; et al. 2020)

Library Design

1. Firstly, a reference set of known molecular regulatory inflammatory targets are obtained from a wide range of commercial databases
2. Then, a 2D fingerprint similarity search is performed against the BOC Sciences HTS compound collection
3. Nearly 1,700 inflammation-related screening compounds are generated successfully

Our library’s targets are:

2D Similarity-based Anti-inflammatory Focused Library Characteristics

• No PAINS or toxic substances/unwanted functions: filtered by strict ‘Ro5-like’ physicochemical and most stringent in-house structural filters
• Bioactivity and safety confirmed by preclinical studies and clinical trials
• Structural diversity, medicinal activity, and cellular penetration
• Structural document, IC₅₀, and other chemical and biological data are provided
• Tanimoto index ≥ 0.8
• All compounds are continually updated
• Compound cherry-picking service is provided

Figure 2. Nonsteroidal anti-inflammatory drugs induce cytoprotection and suppress autophagy. (Xiangjie, F.; et al. 2020)

What We Deliver

• Delivered within 2 weeks in any customer-preferred format
• Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
• All compounds have a minimum purity of 90% assessed by ¹H NMR and HPLC
• Analytical data is provided

BOC Sciences provides professional, rapid and high-quality services of 2D Similarity-based Anti-inflammatory Focused Library design at competitive prices for global customers. Personalized and customized services of 2D Similarity-based Anti-inflammatory Focused Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!