SARS has four major structural proteins, including the structural proteins including spike glycoprotein, small envelope glycoprotein, membrane glycoprotein and the nucleocapsid protein, as well as several accessory proteins. This virus can enter the body through its receptor ACE2, which is present in various organs such as heart, lungs, kidneys and gastrointestinal tract, thus facilitating entry of the virus into target cells. Through recent developments in vaccine-based therapies for cancer and other diseases, therapeutic development efforts have also focused on drug discovery that can stop the spread and replication of the virus in the host cell. To target against different coronaviruses, BOC Sciences has carefully designed a high-quality SARS coronavirus focuse library.
Figure 1. Structure of SARS-CoV2. (Vallamkondu, J.; et al. 2020)
SARS Coronavirus Focuse Library Design
BOC Sciences supports a 2D fingerprint similarity search method with the Tanimoto similarity cut-off (75%) to screen a reference compound set known to be active against SARS coronavirus. The target activities include:
- SARS coronavirus
- SARS coronavirus 3C-like protease
- Replicase polyprotein 1ab
All compounds in the reference set are selected based on acceptable maximum activity values (IC50, KI50<1000 nM, inhibition>25%). As a result, nearly 300 unique compounds are included in the reference set for subsequent similarity searches
SARS Coronavirus Focuse Library Characteristics
- Bioactivity and safety confirmed by preclinical studies and clinical trials
- Structural diversity, medicinal activity, and cellular penetration
- Structural document, IC50, and other chemical and biological data are provided
- All compounds are continually updated
- Compound cherry-picking service is provided
What We Deliver
- Delivered within 2 weeks in any customer-preferred format
- Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
- All compounds have a minimum purity of 90% assessed by 1H NMR and HPLC
- Analytical data is provided
BOC Sciences provides professional, rapid and high-quality services of SARS Coronavirus Focuse Library design at competitive prices for global customers. Personalized and customized services of SARS Coronavirus Focuse Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!
Reference
- Vallamkondu, J.; et al. SARS-CoV-2 pathophysiology and assessment of coronaviruses in CNS diseases with a focus on therapeutic targets. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2020. 1866(10): 165889.
