Human and animal hormones are messenger substances that have specific regulating functions in the cells of their respective effector organs, and therefore can control various physiological processes. Hormones and their derivatives have been widely used in hormone therapy which is a therapeutic approach that adds, blocks or removes hormones. Hormone therapy is beneficial by slowing down or stopping the growth of cancer cells that require hormones for growth. Hormones have a variety of chemical structures and can be divided into 3 main groups: eicosanoids, steroids and amino acid/protein derivatives. Many hormones and their structural and functional analogs are used as drugs, the most commonly used hormones are estrogen and progestin (as a approach of hormonal contraception and HRT), thyroxine (levothyroxine for hypothyroidism) and steroids (for autoimmune diseases and several respiratory diseases). In addition, insulin have be widely used in the treatment of diabetes. It is also necessary to control the growth of hormones used to slow down or stop the growth of cancer cells. Plant hormones are among the most important biochemicals that affect plant growth and crop yield under different conditions. Preliminary studies on plant hormones have identified five major groups: abscisic acid, auxin, cytokinins, ethylene and gibberellins. They are widely used in agriculture as specific treatment agents such as herbicides or as rooting powders. They can also promote flowering and increase the size of fruits.
BOC Sciences can design a hormone-related focused library, which contains analogs of human and animal hormones/hormone-related agents, as well as a variety of plant hormones.
Figure 1. Multiple actions of parathyroid hormone-related protein in breast cancer bone metastasis. (John Martin, T.; Rachelle, W. 2021)
Hormone-related Focused Library Design
At BOC Sciences, the composition of our human hormone related compound library is as follows:
- Neuronal signaling (179 compounds)
- Endocrinology & hormones (140 compounds)
- GPCR & G Protein (81 compounds)
- Metabolism (18 compounds)
- Immunology & Inflammation (13 compounds)
- Others (13 compounds)
- Protein tyrosine kinase (13 compounds)
- Angiogenesis (9 compounds)
- Microbiology (4 compounds)
- Transmembrane transporters (3 compounds)
- Cytoskeletal signaling (2 compounds)
- MAPK (1 compounds)
- P13K/Akt/mTOR (1 compounds)
- Proteases (1 compounds)
Hormone-related Focused Library Characteristics
- The drugs in our library are carefully selected from the BOC Sciences HTS compound collection by employing 2D fingerprinting and Tanimoto similarity index of > 0.75
- A separate set of 90 steroid-like compounds based on gonane scaffold is available
- Our library is a powerful tool for facilitating hormone-related research, high-throughput screening, high-content screening and drug discovery projects
- No PAINS or toxic substances/unwanted functions: filtered by strict ‘Ro5-like’ physicochemical and most stringent in-house structural filters
- Bioactivity and safety confirmed by preclinical studies and clinical trials
- Structural diversity, medicinal activity, and cellular penetration
- Structural document, IC50, and other chemical and biological data are provided
- All compounds are continually updated
- Compound cherry-picking service is provided
What We Deliver
- Delivered within 2 weeks in any customer-preferred format
- Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
- All compounds have a minimum purity of 90% assessed by 1H NMR and HPLC
- Analytical data is provided
BOC Sciences provides professional, rapid and high-quality services of Hormone-related Focused Library design at competitive prices for global customers. Personalized and customized services of Hormone-related Focused Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!
Reference
- John Martin, T.; Rachelle, W. Multiple actions of parathyroid hormone-related protein in breast cancer bone metastasis. British Journal of Pharmacology. 2021. 178(9): 1923-1935.
