PARP1 is a cytonuclease present in eukaryotic cells that catalyzes polyADP ribosylation, and the polyADP ribosanization in which he is involved is one of the important post-translational modifications of proteins in eukaryotic cells. PARP1 is often used as a "sensor" for DNA strand breaks. It has been proven that there is a correlation between high PARP1 expression and treatment-resistance of tumors. Increased PARP1 expression can be observed in melanoma, breast cancer, lung cancer, and other neoplastic diseases. Therefore, PARP1 inhibitors can be utilized as standalone, potent agents against tumors with broken DNA repair mechanisms and are one of the promising molecular targets for the discovery of antitumor drugs.
Aiming to find PARP1 inhibitors as antitumor agents, BOC Sciences can produce a PARP1 targeted library to screen out antitumor drugs.
Figure 1. Mechanism of activation and regulation of PARP-1. (Antolin, A. 2014)
At BOC Sciences, our scientists have established a high-throughput virtual screening method with docking approach to generate this library:
BOC Sciences provides professional, rapid and high-quality services of Poly [ADP-ribose] polymerase 1 (PARP-1) Targeted Library design at competitive prices for global customers. Personalized and customized services of Poly [ADP-ribose] polymerase 1 (PARP-1) Targeted Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!
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BOC Sciences has rich experience in working with global customers in custom library synthesis of compounds and generating small to medium-sized libraries of target compounds. Our knowledge in generating a large number of target molecules in a remarkably shorter time enables quick biological screenings for affinities. With the target properties in mind, we deliver target molecules, by applying our extensive knowledge in drug discovery.