1. Home
  2. Services
  3. Focused/Targeted Library
  4. Nuclear Receptor Screening Library

Nuclear Receptor Screening Library

2D Similarity-based Nuclear Receptor Ligand-Based Library
Docking-based Nuclear Receptor Library

Nuclear receptors (NRs) are ligand-dependent transcription factors that play a key role in reproduction, development and homeostasis of organisms. NRs are a class of proteins responsible for sensing steroids and thyroid hormones as well as a number of other molecules. In response, these receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis and metabolism of the organism. The primary function of the NR is to act as a transcriptional switch in response to lipophilic hormones, vitamins, dietary lipids or other intracellular signals. Thus, nuclear hormone receptors are important drug targets for the treatment of inflammatory diseases, cancer and diabetes.

To address this issue, BOC Sciences has employed various tools to develop two dedicated nuclear receptor screening libraries for drug discovery screening projects in nuclear receptor research.

Modular domain structure of NRs. Figure 1. Modular domain structure of NRs. (Emily, R.; et al. 2018)

Nuclear Receptor Screening Library Design

BOC Sciences’ docking-based nuclear receptor library includes screening compounds selected by protein-ligand docking

We apply 2D fingerprint similarity searches against nuclear receptor bioactivities recorded in the database to build this ligand-based library

NR ligand binding domains. Figure 2. NR ligand binding domains. (Emily, R.; et al. 2018)

Nuclear Receptor Screening Library Characteristics

  • No PAINS or toxic substances/unwanted functions: filtered by strict ‘Ro5-like’ physicochemical and most stringent in-house structural filters
  • Bioactivity and safety confirmed by preclinical studies and clinical trials
  • Structural diversity, medicinal activity, and cellular penetration
  • Structural document, IC50, and other chemical and biological data are provided
  • All compounds are continually updated
  • Compound cherry-picking service is provided

What We Deliver

  • Delivered within 2 weeks in any customer-preferred format
  • Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
  • All compounds have a minimum purity of 90% assessed by 1H NMR and HPLC
  • Analytical data is provided

BOC Sciences provides professional, rapid and high-quality services of Nuclear Receptor Screening Library design at competitive prices for global customers. Personalized and customized services of Nuclear Receptor Screening Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!

Reference

  1. Emily, R.; et al. The nuclear receptor superfamily: A structural perspective. Protein Science. 2018. 27(11): 1876-1892.
Our mission is to provide clients with a professional chemical library design platform. Empowered by high-quality services and effective research solutions, we are committed to helping customers achieve effective and successful research goals.

Online Inquiry

Verification code
Services Based on the Chemical Library Design Platform

Services Based on the Chemical Library Design Platform

BOC Sciences has rich experience in working with global customers in custom library synthesis of compounds and generating small to medium-sized libraries of target compounds. Our knowledge in generating a large number of target molecules in a remarkably shorter time enables quick biological screenings for affinities. With the target properties in mind, we deliver target molecules, by applying our extensive knowledge in drug discovery.

BACK TO TOP