Cathepsin K Targeted Library

Osteoporosis is characterized by low bone mass with skeletal fragility and an increased risk of fracture. This bone loss is caused by an imbalance between bone resorption and formation. Cathepsin K (CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD) is the most abundant expressed cysteine protease in the osteoclasts and is thought to contribute to the degradation of bone matrix necessary for bone resorption. Cathepsin K plays an important role in osteoporosis and other bone-related pathologies, cancer, diabetes, obesity and atherosclerosis. Pharmacologically, effective anti-osteoporosis drugs are able to significantly stimulate bone formation or at least inhibit bone resorption but not bone formation. It seems that cathepsin K inhibitors are better choice which can limit osteoclast activity without reducing osteoblast function. In this way, cathepsin K inhibitors represent a new target for the development of drugs for the treatment of osteoporosis and other diseases characterized by increased bone resorption.

BOC Sciences has developed a cathepsin K targeted library to offer 761 compounds with predicted inhibiting activity against this protease and suitable for the early stage of drug discovery.

Figure 1. Cathepsin K inhibition for the treatment of osteoporosis. (Le, T.; et al. 2016)

Cathepsin K Targeted Library Design

Overall, BOC Sciences has used a receptor-based virtual screen to design this unique library:

1. Firstly, the crystal structure of CTSK is used
2. Then, the BOC Sciences drug-like green collection is applied to be precisely and flexibly docked into the cathepsin K binding pocket
3. Finally, we select compounds by evaluating key structural determinants of the CTSK active site for ligand binding, docking scores, and intermolecular hydrogen bonding to amino acid residues at the key active site

Cathepsin K Targeted Library Characteristics

BOC Sciences’ Cathepsin K targeted library includes a diversity of therapeutically relevant compounds that are carefully selected from our proprietary collection of HTS compounds to meet the parameters listed in the table below.

Table1. The summary of the BOC Sciences Cathepsin K Targeted Library characteristics

Features of Cathepsin K Targeted Library

• All PAIN and reactive compounds are excluded from selection by internal filter applications
• Structurally diverse subset, with the option to favor hit discovery
• Structural analogs available for SAR studies
• All compounds are continually updated
• Compound cherry-picking service is available

What We Deliver

• Delivered within 2 weeks in any customer-preferred format
• Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
• All compounds have a minimum purity of 90% assessed by ¹H NMR and HPLC
• Analytical data is provided

BOC Sciences provides professional, rapid and high-quality services of Cathepsin K Targeted Library design at competitive prices for global customers. Personalized and customized services of Cathepsin K Targeted Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!