DNA-encoded Library (DEL) Design

The development of combinatorial chemistry technology has created a material basis for large-scale drug screening. In order to carry out high-efficiency, fast and low-cost compound screening and maximize the discovery of drugs, high-throughput screening techniques have emerged and developed rapidly. In the field of drug discovery, DNA encoding method is a cutting-edge technology for discovering lead compounds to support the discovery of new drugs. DNA-encoded compound library technology combines the combinatorial chemistry synthetic methods and DNA technology to generate massive compounds. Scientists design DNA-encoded compound libraries to screen hundreds of millions of compounds and discover compounds with novel structures. BOC Sciences has established an advanced DEL technology platform, aiming to speed up and optimize the process of drug research and development, and reducing research and development costs.

Figure 1. DNA-encoded dynamic library (Gang, L.; et al. 2015)

Design of DEL

At BOC Sciences, our chemists have applied both chemistry-driven and biology-driven approaches to design DEL:

Chemistry-driven DEL design

• We have implemented DNA-compatible chemical reactions and synthesis strategies to carry out chemistry-driven library design.
• A diversity drug-like scaffolds and building blocks are also available for the design of DEL.

Biology-driven DEL design

• We have established biology-driven library based on structural information of target types with specific biological effect. Our biology-driven library covers and expands chemical spaces of drugs or bioactive molecules. Our clients are capable of screening hit compounds for known targets and emerging targets using our well developed DEL.

Our Services

To make it easier and better for researchers, BOC Sciences provides DNA-encoded library design in a competitive fashion. We have prepared the most convenient services for you.

• Diverse compound library

Our diverse compound library is composed of known or newly developed DNA compatible reactions based on a combination of molecular building blocks.

• Target/Focused Library

For the targets of interest (such as kinases, bromine domains, etc.) and targets suitable for the development of covalent inhibitors, a target/focused library with unique structural characteristics is established.

Features of Our DNA-encoded Library

• Large storage capacity
• High synthesis efficiency
• Good molecular diversity
• Low cost and short time
• Enable to screen for some protein targets that are unstable or can only be obtained in small amounts

BOC Sciences provides professional, rapid and high-quality services of DNA-encoded library design at competitive prices for global customers. Personalized and customized services of DNA-encoded library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!