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Angiogenesis Library

Angiogenesis refers to the formation of new blood vessels. This process involves the migration, growth and differentiation of endothelial cells, and is controlled by multiple chemical signals in the body, such as vascular endothelial growth factor (VEGF). When VEGF or other endothelial growth factors bind to their receptors on endothelial cells, these intracellular signals are initiated to promote the growth and survival of new blood vessels. Angiogenesis is also an important step in the transition of tumors from a benign to a malignant state. Therefore, angiogenesis plays a critical role in cancer growth, and scientists are committed to investigating the application of different angiogenesis inhibitors in cancer therapy.

BOC Sciences has designed an angiogenesis library to facilitate high-throughput screening of small molecules for angiogenesis-related drug discovery programs.

One strategy to inhibit protease activity by targeting the autolysis loop (colored in magenta). Figure 1. One strategy to inhibit protease activity by targeting the autolysis loop (colored in magenta). (Nyberg, P. 2005)

Angiogenesis Library Design

Abnormal angiogenicity can lead to a variety of diseases and has become a drug target for exploring the pathogenesis of diseases such as cancer and opening up new treatments. BOC Sciences has utilized different techniques to design this unique library which can be applied as useful tools for finding mechanisms for tumor treatment.

  1. Targets space includes:
    • VEGFR, FGFR, PDGFR, EGFR, FLT3, FAK, JAK-1,2, TIE-1,2.
  2. A unique collection of 400 small-molecule compounds for high-throughput screening (HTS) and high-content screening (HCS)
  3. Our angiogenesis related compound library is composed of:
Protein tyrosine kinaseCytoskeletal signaling
AngiogenesisTGF-beta/Smad
JAK/STATDNA damage/DNA repair
Cell-cycleNeuronal signaling
MAPKOthers
Immunology & InflammationPI3K/Akt/mTOR
UbiquitinMetabolism
EpigeneticsAutophagy
Metabolism

Mechanisms of action of angiogenesis inhibitors targeting VEGF, EGF, PDGF, FGF, RET and their receptors for suppressing angiogenesis. Figure 2. Mechanisms of action of angiogenesis inhibitors targeting VEGF, EGF, PDGF, FGF, RET and their receptors for suppressing angiogenesis. (Anna, M. et al. 2016)

Angiogenesis Library Characteristics

  • Favorable physicochemical parameters and solubility requirements
  • No PAINS or toxic substances/unwanted functions: filtered by strict ‘Ro5-like’ physicochemical and most stringent in-house structural filters
  • Bioactivity and safety confirmed by preclinical studies and clinical trials
  • Structural diversity, medicinal activity, and cellular penetration
  • Structural document, IC50, and other chemical and biological data are provided
  • All compounds are continually updated
  • Compound cherry-picking service is provided

What We Deliver

  • Delivered within 2 weeks in any customer-preferred format
  • Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
  • All compounds have a minimum purity of 90% assessed by 1H NMR and HPLC
  • Analytical data is provided

BOC Sciences provides professional, rapid and high-quality services of Angiogenesis Library design at competitive prices for global customers. Personalized and customized services of Angiogenesis Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!

References

  1. Nyberg, P. Endogenous Inhibitors of Angiogenesis. Cancer Research. 2005. 65(10): 3967-3979.
  2. Anna, M.; et al. Angiogenesis Inhibitors in NSCLC. International Journal of Molecular Science. 2017. 18(10).
Our mission is to provide clients with a professional chemical library design platform. Empowered by high-quality services and effective research solutions, we are committed to helping customers achieve effective and successful research goals.

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Services Based on the Chemical Library Design Platform

Services Based on the Chemical Library Design Platform

BOC Sciences has rich experience in working with global customers in custom library synthesis of compounds and generating small to medium-sized libraries of target compounds. Our knowledge in generating a large number of target molecules in a remarkably shorter time enables quick biological screenings for affinities. With the target properties in mind, we deliver target molecules, by applying our extensive knowledge in drug discovery.

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