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Hepatoprotective Compound Library

Globally liver diseases are on the rise, and some of the causes include viral hepatitis, liver cancer, fatty liver disease due to non-alcoholic or too much alcohol consumption, immune disorders, cholestasis and metabolic disorders. Nowadays, liver cirrhosis has already become the seventh leading cause of death. Phytochemicals obtained from plants can be a potential source of drugs for the treatment of liver diseases, such as phenolic acids, phenylpropanoids, lignans, terpenoids, dibenzylenes, curcumin, carotenoids, glycosides, saponins, flavonoids, flavonoid and alkaloid groups of hepatoprotective phytochemicals.

BOC Sciences can design and produce a hepatoprotective compound library, a unique collection of 165 natural compounds, to help perform hepatoprotective research and hepatoprotective drug screening.

Potential anti-inflammatory and anti-fibrotic drug targets and treatments. Figure 1. Potential anti-inflammatory and anti-fibrotic drug targets and treatments. (Ralf, W. 2016)

Library Design

At BOC Sciences, our hepatoprotective compound library can provide 165 drug-like screening compounds with known activity:

D-PinitolScoparoneGinsenoside Ro
BakuchiolVanillic acidLiquiritigenin
PhyllanthinCarnosic acidRhein
NodosinIsoimperatorinPolydatin
GanodermanontriolCudraxanthone LTetrandrine
GanodermanondiolBaicalinSalidroside
Sculponeatin NIsochlorogenic acid CSophocarpine
Sculponeatin OSaikosaponin B2Conophylline
RubiadinTormentic acidSodium Aescinate
Blumeatin10-GingerolDioscin
SyringinGenipinRuscogenin
SilymarinIsoimperatorinEriocitrin
NarirutinEmodin-8-beta-D-glucoside4-Hydroxyisoleucine
BetaineLicochalcone BPectolinarin
Betaine hydrochlorideMulberroside ANuciferine
HispidulinSenkyunolide AAcetylcorynoline
Picroside IISchizandrin C6-O-(3'',4''-Dimethoxycinnamoyl)catalpol

Non-sulfur-containing antioxidants with therapeutic potential in hepatic fibrosis. Figure 1. Non-sulfur-containing antioxidants with therapeutic potential in hepatic fibrosis. (Ralf, W. 2016)

Hepatoprotective Compound Library Characteristics

  • No PAINS or toxic substances/unwanted functions: filtered by strict ‘Ro5-like’ physicochemical and most stringent in-house structural filters
  • Bioactivity and safety confirmed by preclinical studies and clinical trials
  • Structural diversity, medicinal activity, and cellular penetration
  • Structural document, IC50, and other chemical and biological data are provided
  • Tanimoto index ≥ 0.8
  • All compounds are continually updated
  • Compound cherry-picking service is provided

What We Deliver

  • Delivered within 2 weeks in any customer-preferred format
  • Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
  • All compounds have a minimum purity of 90% assessed by 1H NMR and HPLC
  • Analytical data is provided

BOC Sciences provides professional, rapid and high-quality services of Hepatoprotective Compound Library design at competitive prices for global customers. Personalized and customized services of Hepatoprotective Compound Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!

Reference

  1. Ralf, W. Hepatoprotective and Anti-fibrotic Agents: It's Time to Take the Next Step. Frontiers in Pharmacology. 2016. 6: 303.
Our mission is to provide clients with a professional chemical library design platform. Empowered by high-quality services and effective research solutions, we are committed to helping customers achieve effective and successful research goals.

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Services Based on the Chemical Library Design Platform

Services Based on the Chemical Library Design Platform

BOC Sciences has rich experience in working with global customers in custom library synthesis of compounds and generating small to medium-sized libraries of target compounds. Our knowledge in generating a large number of target molecules in a remarkably shorter time enables quick biological screenings for affinities. With the target properties in mind, we deliver target molecules, by applying our extensive knowledge in drug discovery.

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