Anti-inflammatory Screening Compound Library

2D Similarity-based Anti-inflammatory Focused Library

Docking Screening-based Anti-inflammatory Targeted Library

Inflammation is of natural origin, but it can seriously injure the patient, leading to body’s depletion of resources and pain syndrome. The inflammatory process is part of a complex biological response characterized by the following phases: alteration, exudation, proliferation and activation of the immune response. Inflammation can be classified as acute or chronic, depending on the type of cells and molecules involved in the process. Various studies have revealed a set of essential proteins and messengers that are responsible for the development of progressive and slow immune responses. In general, acute inflammation can be well controlled because it can be rapidly diagnosed at an early stage. However, chronic diseases usually show typical features of general diseases and are therefore difficult to diagnose at an early stage. Diseases such as hay fever, periodontitis, atherosclerosis, rheumatoid arthritis and even cancer have demonstrated the involvement of similar pathways with a range of protein targets involved in the development of chronic inflammation.

BOC Sciences can design and produce its Anti-inflammatory Screening Compound Library for novel anti-inflammatory screening and drug discovery research.

Role of inflammation in cancer development. Figure 1. Role of inflammation in cancer development. (Min-Hsiung, P.; et al. 2020)

Library Design

Anti-inflammatory Focused Compound Library via 2D Fingerprint Similarity Search

2D fingerprint similarity refers to a set of reference active compounds and molecules of interest are represented as a set of small fragments encoded in a bit string. We evaluate the degree of similarity between by comparing the two sets of "fingerprints"

Inflammation Targeted Compound Library via Docking Screening

This library is designed based on data of validated protein interaction signaling pathways, available protein structure data and active protein inhibitors. More than 1,200 potential anti-inflammatory agents have been identified using the docking screening approach targeting the BOC Sciences HTS compound collection

Figure 2. Chronic inflammation is linked to human diseases. (Min-Hsiung, P.; et al. 2020)

Anti-inflammatory Screening Compound Library Characteristics

No PAINS or toxic substances/unwanted functions: filtered by strict ‘Ro5-like’ physicochemical and most stringent in-house structural filters
Bioactivity and safety confirmed by preclinical studies and clinical trials
Structural diversity, medicinal activity, and cellular penetration
Structural document, IC₅₀, and other chemical and biological data are provided
Tanimoto index ≥ 0.8
All compounds are continually updated
Compound cherry-picking service is provided

What We Deliver

Delivered within 2 weeks in any customer-preferred format
Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
All compounds have a minimum purity of 90% assessed by ¹H NMR and HPLC
Analytical data is provided

BOC Sciences provides professional, rapid and high-quality services of Anti-inflammatory Screening Compound Library design at competitive prices for global customers. Personalized and customized services of Anti-inflammatory Screening Compound Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!

Reference

Min-Hsiung, P.; et al. Anti-inflammatory activity of natural dietary flavonoids. Food & Function. 2010. 1: 15-31.

Focused/Targeted Library

Our mission is to provide clients with a professional chemical library design platform. Empowered by high-quality services and effective research solutions, we are committed to helping customers achieve effective and successful research goals.

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