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Antioxidants Compound Library

Oxidative stress is defined as an imbalance between oxidants (reactive oxygen species (ROS) and reactive nitrogen species (RNS)) and antioxidants. Under oxidative stress conditions, excess ROS can damage cellular proteins, lipids, and DNA, leading to lethal cellular damage, which in turn is involved in a variety of pathologies, such as aging, cancer, neurodegenerative diseases, cardiovascular diseases, diabetes, etc. The physiological role of ROS is mainly developed based on their ability to regulate multiple signaling pathways, including NF-κB, MAPK, p53, Keap1-Nrf2, and PI3K/AKT, etc. Since oxidative cell damage contributes to the development of cancers, heart disease and aging, the synthesis of antioxidants that can prevent or reduce oxidative stress to cells is an important area of research. Antioxidants are a class of compounds that counteract oxidative stress and mitigate its effects on an individual's health, and have long been an important and treatable arsenal for a variety of diseases such as AD and cancer.

BOC Sciences can employ a combinatorial chemistry approach to design a parallel library of novel antioxidants.

An organic intervention diet. Figure 1. An organic intervention diet. (Hurtado-Barroso, S.; et al. 2019)

Library Design

  1. Our unique antioxidants compound library contains 730 compounds that act as antioxidants, which is designed for high throughput screening (HTS) and high content screening (HCS) campaigns
  2. Targets including: NF-κB, mTOR, Keap1-Nrf2, AMPK, Sirtuin, etc
  3. The composition of this antioxidants compound library:
  • Reactive Oxygen Species
  • Mitophagy
  • Topoisomerase
  • NF-κB
  • Glutathione Peroxidase
  • HIF/HIF Prolyl-Hydroxylase
  • Apoptosis
  • TNF Receptor
  • Interleukin Related
  • Autophagy
  • Akt
  • MDM-2/p53
  • Cytochrome P450
  • Calcium Channel
  • Virus Protease
  • Endogenous Metabolite
  • ERK
  • HBV
  • mTOR
  • PPAR
  • Potassium Channel
  • Toll-like Receptor (TLR)
  • NADPH Oxidase
  • DNA/RNA Synthesis
  • AMPK
  • STAT
  • E1/E2/E3 Enzyme
  • Sirtuin
  • Mitochondrial Metabolism
  • GABA Receptor
  • Keap1-Nrf2
  • SARS-CoV
  • HSV
  • Bacterial
  • DNA-PK
  • IKK
  • P13K
  • Gutathione S-transferase
  • MMP
  • COX
  • p38 MAPK
  • RAR/RXR
  • Ferroptosis
  • Amyloid-β
  • Sodium Channel
  • Fungal
  • JNK
  • AChE
  • NOD-like Receptor (NLR)
  • NO Synthase
  • CDK
  • Parasite
  • P-glycoprotein
  • Dihydroorotate Dehydrogenase
  • HIV
  • MDA-MB-231
  • HCV
  • Antibiotic
  • Melanoma tumor cell line
  • HDAC
  • Influenza Virus
  • MOLT-4
  • JAK
  • Phosphatase
  • Proteasom

Antioxidants Compound Library Characteristics

  • No PAINS or toxic substances/unwanted functions: filtered by strict ‘Ro5-like’ physicochemical and most stringent in-house structural filters
  • Confirmed bioactivity and safety by preclinical studies and clinical trials
  • Structural diversity, significant efficacy, and cellular penetration
  • Structural document, IC50, and other chemical and biological data are provided
  • Tanimoto index ≥ 0.8
  • All compounds are continually updated
  • Compound cherry-picking service is provided

What We Deliver

  • Delivered within 2 weeks in any customer-preferred format
  • Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
  • All compounds have a minimum purity of 90% assessed by 1H NMR and HPLC
  • Analytical data is provided

BOC Sciences provides professional, rapid and high-quality services of Antioxidants Compound Library design at competitive prices for global customers. Personalized and customized services of Antioxidants Compound Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!

Reference

  1. Hurtado-Barroso, S.; et al. Increase of 4-Hydroxybenzoic, a Bioactive Phenolic Compound, after an Organic Intervention Diet. Antioxidants. 2019. 8(9): 340.
Our mission is to provide clients with a professional chemical library design platform. Empowered by high-quality services and effective research solutions, we are committed to helping customers achieve effective and successful research goals.

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Services Based on the Chemical Library Design Platform

Services Based on the Chemical Library Design Platform

BOC Sciences has rich experience in working with global customers in custom library synthesis of compounds and generating small to medium-sized libraries of target compounds. Our knowledge in generating a large number of target molecules in a remarkably shorter time enables quick biological screenings for affinities. With the target properties in mind, we deliver target molecules, by applying our extensive knowledge in drug discovery.

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