There is an increasing demand for peptide tools in experimental and clinical immunology, especially for personalized immunotherapy. Clinical-grade peptides play important role in the development of (new) epitope based vaccines and immunotherapies. However, a large number of specifications available on the market today make it difficult to select the best peptide format for a specific application. Antigen discovery pools are optimal choices for broad antigen target discovery, T-cell epitope discovery and biological screening. In addition, it can also be used for neo-epitope based immune monitoring. BOC Sciences antigen discovery pool consists of overlapping and pooled peptides synthesized by our proprietary ultra-high throughput technology. The peptides are typically synthesized in small quantities, fully automated and purified by dialysis. Our peptide pools service platforms are able to deliver antigen discovery pools very quickly and cost-effectively.
Figure 1. Possible peptide antigen delivery systems peptide antigen-adjuvant conjugates. (Black, M.; et al. 2010)
Our Services
- Our antigen discovery peptide pools are produced at different specifications
- We support different purity of peptide pools that ranges from crude (for drug discovery) to highly purified (for clinical applications)
- Crude peptide pools for antigen target discovery are generated by high-throughput peptide synthesis that are capable of providing tens of thousands of peptides covering entire antigen families or pathogens
- With years of experience in chemical synthesis, our team is also able to produce clinical-grade peptides representing tumor-associated (neo) antigens or pathogen-derived antigens to meet the highest specifications in terms of purity and absence of contaminants
- BOC Sciences has developed several peptide pools in customized formats that have proven useful in critical applications requiring T-cell stimulation
- Our well-characterized peptide pools and individual peptides can be used to measure T-cell responses against known target proteins, discover new target proteins, and identify stimulating peptides from a large pool of candidate peptides
- For clinical applications, peptides and peptide pools are manufactured under line clearance in a low bioburden environment with full analytical coverage
- Our research teams also perform full process traceability and documentation, and stability testing to build our antigen discovery pool that can meet regulatory requirements
- BOC Sciences fully considers the following aspects: peptide length, number and quantity of peptides, purity, contamination avoidance/elimination, stability, QC / QA measures
What we Deliver?
- At BOC Sciences, peptide arrays are provided in a variety of sizes and formats according to the demand of different projects
- LC-MS on marker peptides (up to 8) in final pool to guarantee presence of all peptides within the final pool
- Standard delivery times of around 3-4 weeks depending on different pool size
- Delivered as 96-well plate or 100-tube rack
- CCOA, MS, and HPLC validation data for each peptide before pooling are provided
BOC Sciences provides professional, rapid and high-quality services of Antigen Discovery Pools design at competitive prices for global customers. Personalized and customized services of Antigen Discovery Pools design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!
Reference
- Black, M.; et al. Advances in the design and delivery of peptide subunit vaccines with a focus on Toll-like receptor agonists. Expert Review of Vaccines. 2010. 9(2): 157-73.
