Proline Kinase Library

Protein kinases are usually classified as serine/threonine or tyrosine kinases, with the serine or threonine residues preceding proline (Ser/Thr-Pro) being the main regulatory phosphorylation motifs that play a role in various cellular processes. Proline-directed kinases such as the mitogen-activated protein (MAP) kinase, cyclin-dependent protein kinase 5 (CDK5) and glycogen synthase 3 (GSK3) of the tau protein are associated closely with many human diseases. These kinases and phosphatases play critical roles in various cellular processes such as the cell cycle, transcription and various signal-transduction pathways, as well as in the cancer and Alzheimer's disease. Scientists are investigating proline-directed kinase-dependent pathways to identify rational targets for the therapeutic intervention of Alzheimer's disease and other neurological disorders.

BOC Sciences builds a proline kinase library which contains 2,000 compounds.

Figure 1. DFG-out conformation in PYK2. (Han, S.; et al. 2009)

Library Design

At BOC Sciences, a proline kinase library is designed and constructed by employing the CADD approach based on the corresponding characteristics of proline kinase.

Kinases

• ERKs
• CDKs
• GSK
• JNK
• MAP and related signaling MAPKAPKS

2D structural similarity (Tanimoto) and topological pharmacophores

• Cluster: 730
• Number of screens: 6668
• Common diversity: 0.74
• Singeltones: 215

Proline Kinase Library Characteristics

• We provide multiple topological analogues
• Representative examples of compounds with max, diversity of 1% random selection are available
• Favorable physicochemical parameters and solubility requirements
• No PAINS or toxic substances/unwanted functions: filtered by strict ‘Ro5-like’ physicochemical and most stringent in-house structural filters
• Bioactivity and safety confirmed by preclinical studies and clinical trials
• Structural diversity, medicinal activity, and cellular penetration
• Structural document, IC₅₀, and other chemical and biological data are provided
• All compounds are continually updated
• Compound cherry-picking service is provided

Figure 2. Active site structure of PYK2 in complex with PF-4618433. (Han, S.; et al. 2009)

What We Deliver

• Delivered within 2 weeks in any customer-preferred format
• Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
• All compounds have a minimum purity of 90% assessed by ¹H NMR and HPLC
• Analytical data is provided

BOC Sciences provides professional, rapid and high-quality services of Proline Kinase Library design at competitive prices for global customers. Personalized and customized services of Proline Kinase Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!