Targeted/focused compound libraries include various collections of compounds with in silico predicted affinity to a target protein or predicted biological activity. Compounds of targeted and focused libraries are often used to interact with a individual protein target or a range of related targets such as kinases, ion channels and proteases. BOC Sciences employs a variety of advanced calculation approaches such as molecular docking, pharmacodynamic group modeling, machine learning and similarity search to create one of the most diverse and balanced collections of targeted and focused libraries on the market.
Our dedicated team is committed to providing diverse targeted and focused libraries, and our professional methods include comprehensive analysis of available chemical and biological information, identification of key pathway targets, calculation and "wet biology" assessment of target tractability and potential binding domains. BOC Sciences can also provide custom services based on client needs. Our service is an important tool for you to study the pathogenesis of diseases, the mechanism of drug action and the induction of cell differentiation.
Our Strengths
- Large number of compounds with excellent properties
- Suitable for a wide range of HTS and HCS programs
- Good diversity, higher screening probability and novelty
- High purity(>90%) to meet the purity requirements for drug screening
- Dedicated team of synthetic, calculation and pharmaceutical experts
Figure 1. TOS, focused library synthesis and DOS. (Spring, D. R.; et al. 2008)
Library Design
BOC Sciences focuses its attention on the targets from different protein families: G protein-coupled receptors, protein kinases, ion channels, proteases, epigenetic targets, nuclear receptors, etc. In addition, we offer a focused library of compounds with certain biological activity including anticancer, antiviral, analgesic, antibacterial, etc.
Figure 2. Generalized methods for achieving skeletal diversity. (Spring, D. R.; et al. 2008)
Focused/Targeted Library Characteristics
- No PAINS or toxic substances/unwanted functions: filtered by strict ‘Ro5-like’ physicochemical and most stringent in-house structural filters
- Bioactivity and safety confirmed by preclinical studies and clinical trials
- Structural diversity, medicinal activity, and cellular penetration
- Structural document, IC50, and other chemical and biological data are provided
- Tanimoto index ≥ 0.8
- All compounds are continually updated
- Compound cherry-picking service is provided
What We Deliver
- Delivered within 2 weeks in any customer-preferred format
- Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
- All compounds have a minimum purity of 90% assessed by 1H NMR and HPLC
- Analytical data is provided
BOC Sciences provides professional, rapid and high-quality services of Focused/Targeted Library design at competitive prices for global customers. Personalized and customized services of Focused/Targeted Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!
Reference
- Spring, D. R.; et al. Diversity-oriented synthesis; a spectrum of approaches and results. Organic & Biomolecular Chemistry. 2008. 6(7): 1149-1158.
