Aging is a natural phenomenon that exists in all living organisms. Recent scientific advances in system biology has revealed new cellular path ways related to aging. The causes of aging are assigned to the programmed and damage or error theories. The programmed theory implies that aging is dependent on specific gene regulation, whereas the damage or error theory emphasizes the accumulated internal and environmental damage to the organism. The damage theory proposes nine features that are commonly considered to contribute to the aging process: genomic instability, telomere depletion, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell failure, and altered intercellular communication. However, many findings suggest that certain approaches can delay or prevent aging. A large body of evidence has emerged to support the possibility of radical human health and lifespan extension, particularly through pharmacological regulation of aging. Therefore, scientists are committed to finding anti-aging medicine that can extend human lifespan and healthy lifespan.
BOC Sciences has established an anti-aging library to provide 44,000 anti-aging compounds that can effectively modulate multiple aging pathways, and thus prevent a wide range of age-related diseases.
Figure 1. Aging mechanisms in different hierarchies. (Ding, A. J.; et al. 2017)
Anti-aging Library Design
BOC Sciences has utilized different techniques to design this unique library which can be applied as useful tools for high-throughput screening (HTS) and high-content screening (HCS)
- Machine learning
- Analysis
- Scaffold hopping
- 2D topological & 3D similarity
- Scaffold & target priority/profiling
- CADD
- 2D similarity
- 2D topological analogues and substructure search
- 3D pharmacophore modeling
- Selection
- Focus on novel chemistry
- Scaffold priority
- Internal filters
- Library generation
We have performed a comprehensive data mining to create a reference compounds training set by using reference compounds with reported specific target activity and reference compounds with reported anti-aging activity
A series of novel chemotypes are identified through selection of known hits to specific biological targets as well as based on structural motifs and physico-chemical properties desirable for specific mechanisms of actions
Pathways: caloric restriction, oxidative stress regulation, sirtuins regulation, epigenetic modification, dopaminergic projections
Biological targets: TOR1, SCH9, GCN2, 8002, SIRT1, VEGF, ALOX5, PDE3, PDE7, HTR, CDK1, KCNK1, Serine proteases
Structural chemotypes: antioxidants, flavonoids, quinoids, tetracycline antibiotics, radical traps, aderenergic compounds
Figure 2. Signaling networks in aging. (Ding, A. J.; et al. 2017)
Anti-aging Library Characteristics
- Favorable physicochemical parameters and solubility requirements
- No PAINS or toxic substances/unwanted functions: filtered by strict ‘Ro5-like’ physicochemical and most stringent in-house structural filters
- Bioactivity and safety confirmed by preclinical studies and clinical trials
- Structural diversity, medicinal activity, and cellular penetration
- Structural document, IC50, and other chemical and biological data are provided
- All compounds are continually updated
- Compound cherry-picking service is provided
Table1. The summary of the BOC Sciences Anti-aging Library characteristics
| Parameter | Value |
| MW | 225-450 |
| Number of H Acceptors | 1-8 |
| LogP | 1-6 |
| PSA | 20-120 |
What We Deliver
- Delivered within 2 weeks in any customer-preferred format
- Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
- All compounds have a minimum purity of 90% assessed by 1H NMR and HPLC
- Analytical data is provided
BOC Sciences provides professional, rapid and high-quality services of Anti-aging Library design at competitive prices for global customers. Personalized and customized services of Anti-aging Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!
Reference
- Ding, A. J.; et al. Current Perspective in the Discovery of Anti-aging Agents from Natural Products. Natural Products & Bioprospecting. 2017(7): 335-404.
