Chemistry-driven DEL Design

For chemistry-driven library design, BOC Sciences has developed more than one hundred DNA-compatible chemical reactions to construct diverse drug-like coding small molecules. In addition, we have also designed and synthesized thousands of unique drug-like scaffolds and synthetic building blocks to realize the novelty of compound.

Building block

Building block can be used in a variety of synthetic pathways, and a large number of new compounds can be obtained through primary and secondary reactions. Therefore, building blocks are essential raw materials for pharmaceutical synthesis. Building blocks with rare structures and good physical and chemical parameters can reduce subsequent synthesis steps and are excellent structural modifiers. Building blocks can be seen as as high-level intermediates. For DNA-encoded library design, a wider variety of structure types are needed to increase the structural diversity of the library. DEL technology therefore has higher requirements for the application of building blocks.

Figure 1. Self-assembly and self-replication with building blocks. (Bartolec, B.; et al. 2018)

DNA-compatible chemical reactions

In order to better expand the chemical space of the DNA-encoded compound library, establish a DNA-encoded library with better compound properties, increase the number of active compounds, and improve the properties of emerging compounds. It is necessary to fundamentally increase the diversity of compound library molecules to cover a larger and more drug-like chemical space. Therefore, BOC Sciences has developed more new DNA-compatible chemical reaction types to make the compound structure more compact while effectively reducing the molecular weight.

Figure 2. Dynamically assembly of DNA-linked fragments. (Gang, L.; et al. 2015)

Our Services

To make it easier and better for researchers, BOC Sciences provides chemistry-driven DNA-encoded library design in a competitive fashion. We have provided a more efficient way to increase the number of new drugs, greatly shorten the R&D cycle, and reduce the development costs.

• Our DNA-encoded library is created based on the knowledge of combinatorial chemistry and DNA structure coding. We can synthesize a mixed compound library containing millions of structures at a relatively low cost.
• At BOC Sciences, based on a variety of DNA-compatible chemical reactions and a huge building block reagent library, our DNA-encoded compound library can be used to simultaneously synthesize small organic molecules and screen for drug activity in both split-pool and special compound encoding-decoding manners.
• According to the principle of combination, we use building block technique to make the molecules repeatedly connected to form a large number of molecular groups with diverse structures to form a DNA-encoded library.
• We provide more than 30,000 kinds of bifunctional/trifunctional building blocks with abundant structural branches, and use monofunctional structures as end caps to meet most of the needs of DEL synthesis.

Advantages of Our Services

• Increased synthesis throughput by an order of magnitude higher than that of traditional synthesis methods
• Greatly shorten the synthesis cycle
• Deeply expanding and covering the chemical space of drug-like molecules

BOC Sciences provides professional, rapid and high-quality services of chemistry-driven DNA-encoded library design at competitive prices for global customers. Personalized and customized services of chemistry-driven DNA-encoded library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!