Finding ligand molecules that interact with target protein targets is of great significance to both scientific research and industrial applications. At present, a diversity of drug discovery projects start with finding molecules that interact with known protein targets. High-affinity ligand molecules including large molecules and small molecules are not only potential candidates for future drug development, but also play an important role in basic research. With the development of hybridoma technology and fully humanized antibody technology, various humanized, high-affinity antibody molecules have been developed. BOC Sciences has utilized the knowledge of structural and computational biology to design and develop a biology-driven DNA-encoded library. We support molecular diversity design of DNA-encoded compound library for challenging targets and discovery of small molecular compounds targeted by protein-protein interactions (PPIs).
Figure 1. DNA-encoded chemical libraries design. (Mannocci, L.; et al. 2011)
Our Services
To make it easier and better for researchers, BOC Sciences provides biology-driven DNA-encoded library design in a competitive fashion. We have provided a more efficient way to increase the number of new drugs, greatly shorten the R&D cycle, and reduce the development costs. Our biology-driven DNA-encoded library is established based on either expansion of drugs, experimental drugs and bio-active molecules or structural information of biological targets:
- Developed based on existing drugs or preclinical active molecule
Our DNA-encoded libraries are designed to cover and expand the chemical space, existing drugs, clinical trials and preclinical active molecules. Our experts use privileged structures to construct DNA-encoded libraries.
- Developed based on the structural information of the biological target
We provide the design and construction services of DNA-encoded library based on specific structural information of a certain type or a certain biological target.
Features of Our Services
- Our custom-generated DNA-encoded library can support large-scale parallel processing, determine the relationship between drug structure and activity, and ensure compound selectivity.
- We can screen targets such as membrane proteins that are difficult to purify. This screening mode that is closer to the physiological state can significantly improve the success rate of drug screening, and has been widely used in some companies’ new drug development.
- In addition, BOC Sciences supports a unique drug discovery engine that uses DNA-encoded library phenotype screening to identify new small molecules that bind to E3 ligase.
- Our DNA-encoded compound library can discover selective oral small molecule drugs that may be as effective as their systemic biological counterparts in regulating PPIs.
BOC Sciences provides professional, rapid and high-quality services of biology-driven DNA-encoded library design at competitive prices for global customers. Personalized and customized services of biology-driven DNA-encoded library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!
Reference
- Mannocci, L.; et al. 20 years of DNA-encoded chemical libraries. Chemical Communications. 2011.
