Functional Group Pairing Pattern Recognition (FGPPR)

It is widely recognized that natural products (NPs) are the most essential source of lead compounds in drug development. Most natural products possess complex structures that can offer a variety of three-dimensional scaffolds, which are useful for scientists to explore a broader chemical space. Biology-oriented synthesis has emerged as an important approach for building natural compound libraries. As an essential biosynthesis approach, diversity-oriented synthesis (DOS) is employed to rapidly and effectively prepare scaffolds and stereochemically diverse molecules.

BOC Sciences has introduced a novel approach: FGPPR technique by using DOS for the simple and rapid construction of natural product libraries containing compounds with diverse and highly complex skeletons.

Figure 1. Classical strategies for the total syntheses of NPs. (Zhang, J.; et al. 2014)

B/C/P strategy

In DOS, the B/F/P (Build/Couple/Pair) strategy is the most widely applied approach which is consist of the following three key steps:

• Build

Synthetic blocks are constructed

• Couple

Then, these building blocks are assembled

• Pair

Finally, various FGPs reactions are performed to obtain multiple skeletal structures

Figure 2. The process of identification of hidden FGPPs and a optimized B/C/P procedure. (Zhang, J.; et al. 2014)

Our Strategies

BOC Sciences has designed novel FGPPR method to synthesize complex molecules with structural diversity using the optimized B/C/P algorithm:

• Building block synthesis

• Hidden functional group pairing patterns (FGPPs)
1. We identify the hidden FGPPs in a class of natural products and then ‘depairing’ them to generate dense functionalized precursors
2. The reaction is carried out to provide the precursors through the Build/Couple phase
• Pair

Our scientists perform functional group pairing reactions sequentially to provide NPs and unique natural product-like scaffolds

BOC Sciences Advantages

• We can precisely identify the FGPPs of natural molecules to ensure the increased scaffolds diversity
• Our new methods help to reduce the total number of steps required to synthesize these NPs
• The Build and Couple phase we design is able to generate unified precursors containing desired functional groups present in the NPs

BOC Sciences provides professional, rapid and high-quality services of Functional Group Pairing Pattern Recognition (FGPPR) at competitive prices for global customers. Personalized and customized services of Functional Group Pairing Pattern Recognition (FGPPR) can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!