General Fragment Library

Nowadays, fragment-based drug discovery (FBDD) has become a widely-used strategy in the pharmaceutical industry and scientific research. One of the advantages of this technology is that it can cover more than 1000 chemical spaces with a relatively small library. The results of fragment-based screening largely depend on the quality of the compound, BOC Sciences has therefore created a set of molecules with similar fragments. Our General Fragment Library contains compounds that meet the ‘Rules of Three’ and has good physical and chemical properties.

Figure 1. Molecular shape distribution of fluorinated fragments. (Aretz, J.; et al. 2014)

General Fragments Library Characteristics

BOC Sciences can build General Fragment Library comprising more than 50,000 fragments with MW≤ 300 and ClogP≤ 3.0. In our library design and synthesis, all reactive and unstable molecules have been filtered out from toxic/highly reactive compounds by the in-house filters.

Table1. The summary of the BOC Sciences General Fragments Library characteristics

Features of General Fragments Library

• The following compounds are carefully removed from our General Fragment Library:
1. Compounds containing any atom different to O, N, C, H, Br, I, Cl, F, S, or P
2. Molecules that do not contain aliphatic or aromatic ring
3. Compounds containing more than 4 halogen atoms
4. Fragments that have reactive functional groups which can bear the risk of covalent binding to the target protein
5. Compounds containing functionalities which may result in undesirable effects such as: Cancerogenic, Toxicity, ADME problems, False positives
• The fragment-like molecules possess a wide range of chemical structure dissimilarity
• Our chemical space can be further expanded by our collection of virtual fragment-like molecules which is readily synthesized through in-house developed and validated synthetic procedures
• BOC Sciences supports customized General Fragment Library design based on your requirements
• Cherry picking is available

What We Deliver

• Delivered within 2 weeks in any customer-preferred format
• Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
• All compounds have a minimum purity of 90% assessed by ¹H NMR
• Analytical data is provided

BOC Sciences provides professional, rapid and high-quality services of General Fragment Library design at competitive prices for global customers. Personalized and customized services of General Fragment Library design an satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!