Carboxylic Acid Fragment Library

A direct comparison between data and the corresponding carboxylic acid helps medicinal chemists to find the best replacement to be used. In response to high demand for new and small carboxylic acid, BOC Sciences has built a set of carefully selected specific molecules that strictly respond to FBDD requirements. This small library of fragments obtained by employing our strategies have showed good versatility both in synthetic and physico-chemical properties.

Figure 1. Stereoselective synthesis and properties of carbocarboxylic acid acceptor fragment containing nonlinear optical chromophores. (Traskovskis, K.; et al. 2016)

Applications of Carboxylic Acid Fragment Library

Hit finding on new and difficult targets
Protein-protein interaction studies

Carboxylic Acid Fragment Library Characteristics

At BOC Sciences, we have designed a Carboxylic Acid Fragment Library containing about 4,000 compounds that is established for specific protein targets and sensible onset. Our Carboxylic Acid Fragment Library is one of the largest and most reliable source of high-quality fragments. We cooperate with leading experts in the field of FBDD to design and supply top-level fragment libraries, aiming to meet needs of each client.

Table1. The summary of the BOC Sciences Carboxylic Acid Fragment Library characteristics

Parameter	Value
MW	≤300
ClogP	-1.5-4.5
Number of Rotatable Bonds	≤4
Number of H Donors	≤4
Number of H Acceptors	≤5
Number of Rings	>0
Compounds with ‘undesirable’ functionalities	Removed
Fsp3	0-1
TPSA	<120 Å2

Features of Carboxylic Acid Fragment Library

No PAINS, REOS or toxic substances/unwanted functions: filtered by previously reported and internally developed pharmaceutical chemical filters
Our carboxylic acid fragments are mainly consist from the compounds derived in the latest years from previously established at BOC Sciences in-house program for design and producing diverse carboxylic acids to enlarge significantly the diversification of decorating reagents
The discovered initial hit usually has high solubility and good membrane permeability
Our well-designed library supports phenotypic screening or in vivo activity of following investigation
Our teams have created carboxylic acid fragments by following the principles of high novelty and core diversity
Fast follow-up with stock available analogues and synthesis are supported
Cherry picking service is available

What We Deliver

Delivered within 2 weeks in any customer-preferred format
Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
All compounds have a minimum purity of 90% assessed by ¹H NMR
Analytical data is provided

BOC Sciences provides professional, rapid and high-quality services of Carboxylic Acid Fragment Library design at competitive prices for global customers. Personalized and customized services of Carboxylic Acid Fragment Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!

Reference

Traskovskis, K.; et al. Stereoselective synthesis and properties of 1,3-bis(dicyanomethylidene)indane-5-carboxylic acid acceptor fragment containing nonlinear optical chromophores. Journal of Materials Chemistry C. 2016. 4(22): 5019-5030.

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Services Based on the Chemical Library Design Platform

BOC Sciences has rich experience in working with global customers in custom library synthesis of compounds and generating small to medium-sized libraries of target compounds. Our knowledge in generating a large number of target molecules in a remarkably shorter time enables quick biological screenings for affinities. With the target properties in mind, we deliver target molecules, by applying our extensive knowledge in drug discovery.

Our mission is to provide clients with a professional chemical library design platform. Empowered by high-quality services and effective research solutions, we are committed to helping customers achieve effective and successful research goals.