A direct comparison between data and the corresponding carboxylic acid helps medicinal chemists to find the best replacement to be used. In response to high demand for new and small carboxylic acid, BOC Sciences has built a set of carefully selected specific molecules that strictly respond to FBDD requirements. This small library of fragments obtained by employing our strategies have showed good versatility both in synthetic and physico-chemical properties.
Figure 1. Stereoselective synthesis and properties of carbocarboxylic acid acceptor fragment containing nonlinear optical chromophores. (Traskovskis, K.; et al. 2016)
Applications of Carboxylic Acid Fragment Library
- Hit finding on new and difficult targets
- Protein-protein interaction studies
Carboxylic Acid Fragment Library Characteristics
At BOC Sciences, we have designed a Carboxylic Acid Fragment Library containing about 4,000 compounds that is established for specific protein targets and sensible onset. Our Carboxylic Acid Fragment Library is one of the largest and most reliable source of high-quality fragments. We cooperate with leading experts in the field of FBDD to design and supply top-level fragment libraries, aiming to meet needs of each client.
Table1. The summary of the BOC Sciences Carboxylic Acid Fragment Library characteristics
| Parameter | Value |
| MW | ≤300 |
| ClogP | -1.5-4.5 |
| Number of Rotatable Bonds | ≤4 |
| Number of H Donors | ≤4 |
| Number of H Acceptors | ≤5 |
| Number of Rings | >0 |
| Compounds with ‘undesirable’ functionalities | Removed |
| Fsp3 | 0-1 |
| TPSA | <120 Å2 |
Features of Carboxylic Acid Fragment Library
- No PAINS, REOS or toxic substances/unwanted functions: filtered by previously reported and internally developed pharmaceutical chemical filters
- Our carboxylic acid fragments are mainly consist from the compounds derived in the latest years from previously established at BOC Sciences in-house program for design and producing diverse carboxylic acids to enlarge significantly the diversification of decorating reagents
- The discovered initial hit usually has high solubility and good membrane permeability
- Our well-designed library supports phenotypic screening or in vivo activity of following investigation
- Our teams have created carboxylic acid fragments by following the principles of high novelty and core diversity
- Fast follow-up with stock available analogues and synthesis are supported
- Cherry picking service is available
What We Deliver
- Delivered within 2 weeks in any customer-preferred format
- Powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates
- All compounds have a minimum purity of 90% assessed by 1H NMR
- Analytical data is provided
BOC Sciences provides professional, rapid and high-quality services of Carboxylic Acid Fragment Library design at competitive prices for global customers. Personalized and customized services of Carboxylic Acid Fragment Library design can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!
Reference
- Traskovskis, K.; et al. Stereoselective synthesis and properties of 1,3-bis(dicyanomethylidene)indane-5-carboxylic acid acceptor fragment containing nonlinear optical chromophores. Journal of Materials Chemistry C. 2016. 4(22): 5019-5030.
